PT-141 Peptide

€53.09

Technical Specifications

Specification	Detail
Product Name	PT-141 Peptide (Bremelanotide)
Quantity	10mg per vial
Purity	≥99% (HPLC verified)
Form	Lyophilized powder
Appearance	White to off-white lyophilized powder
Molecular Weight	~1025 Da
CAS Number	189691-06-3
Molecular Formula	C₅₀H₆₈N₁₄O₁₀
Amino Acid Sequence	Ac-Nle4-Asp5-His6-D-Phe7-Arg8-Trp9-Lys10 α-MSH4-10-NH₂
Structure	Cyclic heptapeptide with lactam bridge
Target Receptors	MC3R, MC4R
Key Research Areas	Sexual behaviour, libido, erectile function, female sexual desire, melanocortin receptor pharmacology, appetite regulation, neuroendocrinology
Storage (Lyophilized)	-20°C; protect from light and moisture
Storage (Reconstituted)	2-8°C for short-term; aliquot and store at -20°C for longer storage
Shelf Life	24 months from manufacture date (lyophilized)
Shipping	Ambient temperature with protective packaging
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

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Premium PT-141 (Bremelanotide) Research Peptide for Sale | 10mg Lyophilized Powder | ≥99% Purity | 48-Hour Delivery Across EU & UK

PT-141 (Bremelanotide): The Advanced Melanocortin Receptor Agonist for Sexual Behaviour Research

Buy PT-141 Peptide EU & UK, Eupharmaceutical is proud to present PT-141 Peptide (Bremelanotide), a premium research-grade cyclic heptapeptide manufactured to the highest analytical standards. As a trusted peptide vendor uk and leading EU peptide supplier, we provide researchers across Europe with PT-141 for sale that delivers exceptional purity, consistency, and documented quality for advanced studies in sexual behaviour, melanocortin receptor pharmacology, and neuroendocrine regulation. Buy PT-141 Peptide EU & UK

PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH) developed from the structure of Melanotan II (MT-2) . While MT-2 was designed primarily for melanogenesis research, PT-141 was specifically engineered to enhance activity at melanocortin receptors involved in sexual function while minimizing effects on pigmentation . The peptide has the cyclic structure Ac-Nle4-Asp5-His6-D-Phe7-Arg8-Trp9-Lys10 α-MSH4-10-NH₂, with the crucial D-Phe-7 substitution that contributes to its superagonist properties at melanocortin receptors .

The molecular formula of PT-141 is C₅₀H₆₈N₁₄O₁₀, with a molecular weight of approximately 1025 Da . Its cyclic structure, stabilized by a lactam bridge, confers significant stability and enhanced receptor binding affinity at specific melanocortin receptor subtypes . PT-141 acts as a non-selective agonist of melanocortin receptors, with particular activity at MC3R and MC4R, which are key mediators of sexual behaviour and arousal. Buy PT-141 Peptide EU & UK. p s y c h e d e l i c g u i d e e x p l a i ned.

PT-141 has been extensively studied in clinical research for its effects on sexual function and has received FDA approval as a treatment for hypoactive sexual desire disorder (HSDD) in premenopausal women under the brand name Vyleesi . For researchers seeking to buy peptide online EU for investigations into sexual behaviour, melanocortin receptor signaling, or neuroendocrine regulation, Eupharmaceutical offers this premium research compound with comprehensive documentation, including Certificates of Analysis and batch-specific purity data. Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our guaranteed 48 hour delivery peptide service ensures your research continues without interruption.

The Scientific Foundation of PT-141 (Bremelanotide) Research

Discovery and Development

PT-141 was developed from the structure of Melanotan II (MT-2), a cyclic heptapeptide analog of α-MSH originally designed for melanogenesis research . During clinical trials with MT-2, researchers observed a notable effect on sexual function, including spontaneous penile erections and increased libido . This finding prompted the development of PT-141, a modified version of MT-2 specifically optimized for activity at melanocortin receptors involved in sexual behaviour while minimizing the pigmentation effects associated with MC1R activation .

The peptide received FDA approval in 2019 as Vyleesi (bremelanotide) for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women, marking a significant milestone in sexual medicine .

Mechanism of Action: Melanocortin Receptor Activation

PT-141 exerts its effects through selective activation of melanocortin receptors, particularly MC3R and MC4R, which are expressed in brain regions involved in sexual behaviour and arousal .

MC4R Activation: The melanocortin-4 receptor (MC4R) is a key mediator of sexual behaviour. Activation of MC4R in the hypothalamus and other brain regions stimulates pathways involved in sexual arousal, desire, and erectile function . Studies have shown that MC4R activation increases dopamine release in the medial preoptic area, a critical region for male sexual behaviour .

MC3R Activation: The melanocortin-3 receptor (MC3R) also contributes to sexual function regulation, with effects on energy homeostasis and reproductive behaviour . Activation of MC3R may modulate the motivational aspects of sexual behaviour .

Minimal MC1R Activity: Unlike MT-2, PT-141 was engineered to have reduced activity at MC1R, the receptor primarily responsible for melanogenesis . This reduces the pigmentation effects associated with melanocortin agonists, making PT-141 a more targeted tool for sexual behaviour research .

Central Nervous System Action: PT-141 acts centrally within the brain, crossing the blood-brain barrier to directly affect neural circuits controlling sexual arousal and behaviour . It does not rely on peripheral vascular effects, distinguishing it from other classes of sexual dysfunction treatments .

Pharmacokinetic Profile

PT-141 is typically administered subcutaneously in research models, with a pharmacokinetic profile characterized by:

Absorption: Rapid absorption following subcutaneous administration, with peak plasma concentrations achieved within 30-60 minutes
Half-Life: Approximately 2-3 hours in humans
Duration of Effect: Biological effects on sexual function persist for several hours after administration
Metabolism: Metabolized via peptide degradation pathways; no active metabolites identified

Key Research Applications

Sexual Function and Behaviour Research

PT-141 is extensively used in studies investigating the neurobiology of sexual behaviour and arousal:

Sexual Arousal: Investigate the neural mechanisms underlying sexual arousal and desire
Erectile Function: Study the central pathways regulating penile erection and sexual response
Female Sexual Desire: Research the neuroendocrine regulation of female sexual desire and arousal
Hypoactive Sexual Desire Disorder (HSDD): Explore the pathophysiology and potential treatments for HSDD
Sexual Motivation: Investigate the motivational aspects of sexual behaviour and reward

Melanocortin Receptor Pharmacology

PT-141 serves as a valuable tool for studying melanocortin receptor signaling:

MC4R Signaling: Investigate MC4R-mediated pathways in sexual behaviour, appetite regulation, and energy homeostasis
MC3R Function: Study the role of MC3R in reproductive behaviour and metabolic regulation
Receptor Selectivity: Explore the structure-activity relationships of melanocortin receptor agonists
G Protein-Coupled Receptor (GPCR) Research: Investigate GPCR signaling mechanisms and downstream effectors. m a g i c m u s h r o o m s.

Appetite and Energy Balance Research

MC4R is a key regulator of appetite and energy balance, making PT-141 relevant for metabolic research:

Appetite Regulation: Study MC4R-mediated effects on food intake and satiety
Energy Homeostasis: Investigate the role of melanocortin pathways in body weight regulation
Obesity Research: Explore the relationship between melanocortin signalling and metabolic disorders

Neuroendocrinology and Stress Research

PT-141 influences multiple neuroendocrine pathways:

Hypothalamic-Pituitary-Gonadal (HPG) Axis: Investigate interactions between melanocortin signalling and reproductive hormone regulation
Stress Response: Study the effects of melanocortin activation on stress-related behaviours and HPA axis function
Dopamine Pathways: Explore the interaction between melanocortin receptors and mesolimbic dopamine circuits

Women’s Health Research

PT-141 has particular relevance for research in women’s health:

Female Sexual Dysfunction: Investigate the neurobiology of female sexual desire and arousal disorders
Hormonal Influences: Study the interaction between melanocortin signalling and ovarian hormones
Menopause Research: Explore the effects of PT-141 on sexual function in perimenopausal and postmenopausal models

Quality Assurance: Setting the Standard for Research Compounds

Manufacturing Excellence

Eupharmaceutical sources PT-141 Peptide from certified GMP facilities with rigorous quality control protocols:

HPLC Purity Analysis: ≥99% purity verified by high-performance liquid chromatography
Mass Spectrometry Verification: Molecular weight confirmation via LC-HRMS
Batch-Specific Certificates of Analysis: Complete documentation for each production run
Research-Use Only (RUO) Labeling: Full compliance with research compound regulations

Chemical and Product Specifications

Specification	Detail
Product Name	PT-141 Peptide (Bremelanotide)
CAS Number	189691-06-3
Molecular Formula	C₅₀H₆₈N₁₄O₁₀
Molecular Weight	~1025 Da
Amino Acid Sequence	Ac-Nle4-Asp5-His6-D-Phe7-Arg8-Trp9-Lys10 α-MSH4-10-NH₂
Structure	Cyclic heptapeptide with lactam bridge
Purity	≥99% (HPLC verified)
Appearance	White to off-white lyophilized powder
Form	Lyophilized powder
Solubility	Soluble in sterile water, bacteriostatic water, or PBS
Target Receptors	MC3R, MC4R (melanocortin receptors)
Storage (Lyophilized)	-20°C; protect from light and moisture
Storage (Reconstituted)	2-8°C for short-term; aliquot and store at -20°C for longer storage
Shelf Life	24 months from date of manufacture (lyophilized)
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

Stability and Handling Guidelines

Lyophilized Powder Storage: Store lyophilized PT-141 powder at -20°C in a dry, dark environment, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 24 months from the date of manufacture.

Reconstitution Protocol:

Allow vial and solvent to reach ambient temperature before opening to prevent condensation
Reconstitute using sterile bacteriostatic water or appropriate buffer according to research protocol
Inject solvent slowly down the inside wall of the vial to minimize foaming
Gently swirl or roll the vial until fully dissolved do not shake vigorously
Label the vial with the date of reconstitution
Refrigerate immediately at 2-8°C

Reconstituted Solution Storage: Store reconstituted PT-141 at 2-8°C for short-term use. For longer-term storage, aliquot into single-use portions and store at -20°C . Avoid repeated freeze-thaw cycles.

Protection from Light and Moisture:

Store in original packaging protected from light
Keep vials tightly sealed when not in use
Allow refrigerated vials to reach room temperature before opening to prevent condensation

Key Benefits

Premium Quality Manufacturing: GMP-certified production, ≥99% HPLC-verified purity with lot-specific COAs
FDA-Approved Research Tool: Bremelanotide received FDA approval in 2019 for HSDD research
Selective MC3R/MC4R Agonist: Engineered for reduced MC1R activity, minimizing pigmentation effects
Sexual Behaviour Research: Investigate neural mechanisms of sexual arousal, desire, and erectile function
Female Sexual Desire Studies: Research pathophysiology and treatment of hypoactive sexual desire disorder
Melanocortin Receptor Pharmacology: Study MC3R/MC4R signaling pathways and structure-activity relationships
Appetite Regulation Research: Investigate MC4R-mediated effects on food intake and energy balance
Neuroendocrinology: Explore interactions with HPG axis, dopamine pathways, and stress responses
Central Nervous System Action: Crosses blood-brain barrier to directly affect neural circuits
Well-Characterized Pharmacokinetics: 2-3 hour half-life with rapid absorption
Clinically Validated: Extensively studied in Phase 2 and Phase 3 clinical trials
Comprehensive Documentation: Certificates of Analysis with batch-specific purity data
48-Hour EU & UK Delivery: Rapid shipping to research facilities across Europe
Batch Consistency: Rigorous quality control ensures lot-to-lot reproducibility
EU Sourced: Available from within the European Union

Frequently Asked Questions

Q: What is PT-141 and how does it work?

A: PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide analog of α-MSH that acts as a selective agonist of melanocortin receptors MC3R and MC4R . It activates neural circuits in the hypothalamus and other brain regions involved in sexual arousal and behaviour, promoting sexual desire and facilitating erectile function .

Q: What purity level can I expect when I buy PT-141 from Eupharmaceutical?

A: All PT-141 Peptide from Eupharmaceutical is tested to ≥99% purity by HPLC, with Certificates of Analysis provided with every order . Each batch is individually analyzed, ensuring you receive material suitable for rigorous research applications. Be s t p syc h e d e l i c t h e r a p y e x p l a i n e d

Q: What is the molecular weight and CAS number of PT-141?

A: PT-141 has a molecular weight of approximately 1025 Da and CAS number 189691-06-3 . Its molecular formula is C₅₀H₆₈N₁₄O₁₀ and its structure is a cyclic heptapeptide with a lactam bridge .

Q: How should I store PT-141 for long-term stability?

A: Store lyophilized PT-141 powder at -20°C, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 24 months. For short-term use, store reconstituted solution at 2-8°C; for longer-term storage, aliquot and store at -20°C .

Q: What is the solubility of PT-141?

A: PT-141 is soluble in sterile water, bacteriostatic water, and PBS . Reconstitute according to research protocol to achieve desired concentration.

Q: What research areas commonly use PT-141?

A: PT-141 is widely used in sexual function and behaviour research, melanocortin receptor pharmacology studies, appetite and energy balance research, neuroendocrinology, and women’s health research .

Q: What is the difference between PT-141 and Melanotan II?

A: PT-141 was developed from the structure of Melanotan II (MT-2) with modifications to enhance activity at MC3R and MC4R (sexual function) while reducing activity at MC1R (pigmentation). PT-141 has minimal effects on skin pigmentation compared to MT-2 .

Q: Do you ship PT-141 to EU countries?

A: Yes. As a dedicated EU peptide supplier, we ship PT-141 Peptide to all European Union member states with our guaranteed 48 hour delivery peptide service. Our EU fulfilment centre ensures rapid delivery without customs delays. All shipments use protective packaging to maintain compound integrity during transit.

Q: What documentation do you provide with PT-141 orders?

A: Every order includes a Certificate of Analysis (COA) with batch-specific purity data . Additional documentation, including HPLC chromatograms and mass spectrometry data, is available upon request for researchers requiring comprehensive analytical verification.

Q: Do you offer bulk quantities of PT-141 for institutional research?

A: Yes. We accommodate bulk orders for research institutions. Contact our team at sales@eupeptidelap.co.uk for volume pricing, custom requirements, and supply agreements for ongoing research programs.

Advance Your Research with PT-141 Peptide

Eupharmaceutical is your trusted source for PT-141 Peptide, the premium choice for researchers investigating sexual behaviour, melanocortin receptor pharmacology, and neuroendocrine regulation. With FDA approval for HSDD and extensive clinical research establishing its role as a selective MC3R/MC4R agonist, PT-141 represents a sophisticated tool for exploring the complex biology of sexual arousal and desire.

Whether you are exploring the neural mechanisms of sexual behaviour, designing melanocortin receptor studies, investigating female sexual desire disorders, or researching appetite regulation pathways, our rigorously tested compound provides the quality and consistency your work demands.

Order today and experience the Eupharmaceutical difference – premium quality, rapid 48-hour delivery across the EU and UK, and expert support for the European research community.