DSIP Peptide

Price range: €42.99 through €429.99

Technical Specifications

Specification	Detail
Product Name	DSIP Peptide (Delta Sleep-Inducing Peptide)
Quantity	10mg per vial
Purity	≥99% (HPLC verified)
Form	Lyophilized powder
Appearance	White to off-white lyophilized powder
Molecular Weight	848.9 g/mol
CAS Number	62568-57-4
Molecular Formula	C₃₅H₄₈N₁₀O₁₅
Amino Acid Sequence	Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Key Research Areas	Sleep architecture, delta sleep, circadian rhythms, stress response, neuroprotection, neuroendocrinology
Storage (Lyophilized)	-20°C; protect from light and moisture
Storage (Reconstituted)	2-8°C for short-term; aliquot and store at -20°C for longer storage
Shelf Life	24 months from manufacture date (lyophilized)
Shipping	Ambient temperature with protective packaging
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

5mg

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Premium DSIP (Delta Sleep-Inducing Peptide) for Sale | 10mg Lyophilized Powder | ≥99% Purity | 48-Hour Delivery Across EU & UK

DSIP Peptide: The Pioneering Sleep-Regulating Nonapeptide for Advanced Research

Buy DSIP Peptide EU & UK, Eupharmaceutical is proud to present DSIP Peptide (Delta Sleep-Inducing Peptide), a premium research-grade nonapeptide manufactured to the highest analytical standards. As a trusted peptide vendor uk and leading EU peptide supplier, we provide researchers across Europe with DSIP for sale that delivers exceptional purity, consistency, and documented quality for advanced studies in sleep architecture, circadian rhythm regulation, and neuroendocrine function. Buy DSIP Peptide EU & UK

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated in 1977 by Swiss researchers Schoenenberger and Monnier from the cerebral venous blood of rabbits during sleep . The peptide has the amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, with a molecular weight of approximately 848.9 g/mol and molecular formula C₃₅H₄₈N₁₀O₁₅ . Its discovery marked a significant milestone in sleep research, providing the first identified substance capable of specifically promoting delta sleep the deepest stage of non-REM sleep. Buy DSIP Peptide EU & UK

DSIP was originally isolated from the cerebral venous blood of rabbits during sleep, and subsequent research confirmed its presence in various species, including humans, suggesting an evolutionarily conserved role in sleep regulation . The peptide has been shown to cross the blood-brain barrier and act on specific receptors in the brain, particularly in the hypothalamus and brainstem regions involved in sleep-wake regulation . Its effects on sleep are dose-dependent and exhibit a bell-shaped response curve, with optimal effects at specific concentration ranges .

For researchers seeking to buy peptide online EU for investigations into sleep architecture, circadian rhythms, stress responses, or neuroendocrine regulation, Eupharmaceutical offers this premium research compound with comprehensive documentation, including Certificates of Analysis and batch-specific purity data. Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our guaranteed 48 hour delivery peptide service ensures your research continues without interruption.

The Scientific Foundation of DSIP Peptide Research

Discovery and Historical Significance

DSIP was first identified in 1977 by Schoenenberger and Monnier during experiments designed to isolate sleep-promoting substances from the cerebral venous blood of rabbits . The researchers observed that blood collected from sleeping rabbits contained a factor that induced delta sleep when injected into recipient animals. This factor was subsequently purified and characterized as a nonapeptide, named Delta Sleep-Inducing Peptide (DSIP) .

The discovery of DSIP was groundbreaking because it provided the first identified endogenous substance specifically capable of promoting delta sleep (slow-wave sleep), establishing that sleep is regulated by specific molecular signals rather than simply being a passive state. Be s t p syc h e d e l i c t h e r a p y e x p l a i n e d

Molecular Structure and Properties

DSIP is a nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu . Its molecular structure is characterized by:

Molecular Formula: C₃₅H₄₈N₁₀O₁₅
Molecular Weight: 848.9 g/mol
Isoelectric Point: Approximately 4.0
Solubility: Highly soluble in water and aqueous buffers
Stability: Stable in solution at 4°C; can be stored frozen for extended periods

The peptide contains a tryptophan residue at the N-terminus, which is critical for its biological activity, and a glutamic acid at the C-terminus, which influences receptor binding . DSIP is rapidly degraded in serum by proteolytic enzymes, with a plasma half-life of approximately 4-7 minutes in humans .

Mechanism of Action

DSIP exerts its effects through specific binding to receptors in the central nervous system, particularly in the hypothalamus and brainstem . Research has identified DSIP-binding sites in various brain regions, including:

Hypothalamus: Particularly the preoptic area and suprachiasmatic nucleus
Brainstem: Reticular formation and raphe nuclei
Limbic System: Hippocampus and amygdala

Upon receptor binding, DSIP modulates multiple neurotransmitter systems involved in sleep-wake regulation:

GABAergic System: DSIP enhances GABAergic transmission in the hypothalamus, promoting sleep onset and maintenance .

Serotonergic System: The peptide influences serotonin release in the raphe nuclei, contributing to sleep regulation .

Orexin/Hypocretin System: DSIP may modulate orexinergic neurons in the lateral hypothalamus, which are critical for maintaining wakefulness .

Melatonin Interaction: Research suggests DSIP may influence pineal melatonin secretion, contributing to circadian rhythm entrainment .

Physiological Effects

Beyond its primary role in sleep promotion, DSIP exhibits multiple physiological effects that make it valuable for diverse research applications:

Sleep Architecture: DSIP specifically promotes delta sleep (slow-wave sleep, NREM stage 3) without affecting REM sleep duration . This specificity makes it a valuable tool for studying the molecular mechanisms underlying deep sleep.

Circadian Rhythm Modulation: DSIP influences the timing and entrainment of circadian rhythms through effects on the suprachiasmatic nucleus (SCN), the master circadian clock .

Stress Response: The peptide modulates the hypothalamic-pituitary-adrenal (HPA) axis, reducing stress-induced cortisol elevation . Studies have shown DSIP can attenuate stress responses in animal models .

Neuroprotection: Research suggests DSIP has neuroprotective properties, protecting neurons against excitotoxicity and oxidative stress .

Thermoregulation: DSIP influences body temperature regulation, which is closely linked to sleep-wake cycles .

Key Research Applications

Sleep Architecture and Delta Sleep Research

DSIP is extensively used in studies investigating sleep structure and the molecular mechanisms of deep sleep:

Delta Sleep Promotion: DSIP specifically increases delta wave activity (0.5-4 Hz) during non-REM sleep, making it a valuable tool for studying slow-wave sleep regulation
Sleep-Wake Cycle: Investigate the effects of DSIP on sleep onset latency, total sleep time, and sleep stage distribution
Sleep Homeostasis: Study the relationship between sleep pressure and delta power using DSIP as a probe

Circadian Rhythm Research

DSIP influences the timing and entrainment of circadian rhythms:

Suprachiasmatic Nucleus (SCN): Investigate DSIP effects on SCN neuronal firing patterns and clock gene expression
Phase Shifting: Study the effects of DSIP on circadian phase resetting and entrainment to light-dark cycles
Circadian Output: Examine DSIP modulation of circadian rhythms in locomotor activity, body temperature, and hormone secretion

Stress Response and HPA Axis Research

DSIP modulates the stress response through effects on the hypothalamic-pituitary-adrenal (HPA) axis:

Cortisol Regulation: Investigate DSIP effects on stress-induced cortisol elevation
CRH Modulation: Study DSIP interactions with corticotropin-releasing hormone (CRH) neurons
Stress-Induced Sleep Disturbance: Explore DSIP as a tool for studying sleep disruption following stress

Neuroprotection Research

DSIP has demonstrated neuroprotective properties in various experimental models:

Excitotoxicity: Study DSIP protection against glutamate-induced neuronal damage
Oxidative Stress: Investigate DSIP effects on reactive oxygen species (ROS) production and antioxidant defense
Ischemia: Explore DSIP protection against cerebral ischemia and reperfusion injury

Neuroendocrine Research

DSIP influences multiple neuroendocrine systems:

Melatonin Secretion: Investigate DSIP effects on pineal melatonin production
Growth Hormone: Study DSIP interactions with growth hormone-releasing hormone (GHRH) and somatostatin
Prolactin: Examine DSIP modulation of prolactin release. m a g i c m u s h r o o m s.

Quality Assurance: Setting the Standard for Research Compounds

Manufacturing Excellence

Eupharmaceutical sources DSIP Peptide from certified GMP facilities with rigorous quality control protocols:

HPLC Purity Analysis: ≥99% purity verified by high-performance liquid chromatography
Mass Spectrometry Verification: Molecular weight confirmation via LC-HRMS
Batch-Specific Certificates of Analysis: Complete documentation for each production run
Research-Use Only (RUO) Labeling: Full compliance with research compound regulations

Chemical and Product Specifications

Specification	Detail
Product Name	DSIP Peptide (Delta Sleep-Inducing Peptide)
CAS Number	62568-57-4
Molecular Formula	C₃₅H₄₈N₁₀O₁₅
Molecular Weight	848.9 g/mol
Amino Acid Sequence	Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Purity	≥99% (HPLC verified)
Appearance	White to off-white lyophilized powder
Form	Lyophilized powder
Solubility	Soluble in sterile water, bacteriostatic water, or PBS
Storage (Lyophilized)	-20°C; protect from light and moisture
Storage (Reconstituted)	2-8°C for short-term; aliquot and store at -20°C for longer storage
Shelf Life	24 months from date of manufacture (lyophilized)
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

Stability and Handling Guidelines

Lyophilized Powder Storage: Store lyophilized DSIP powder at -20°C in a dry, dark environment, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 24 months from the date of manufacture.

Reconstitution Protocol:

Allow vial and solvent to reach ambient temperature before opening to prevent condensation
Reconstitute using sterile bacteriostatic water or appropriate buffer according to research protocol
Inject solvent slowly down the inside wall of the vial to minimize foaming
Gently swirl or roll the vial until fully dissolved—do not shake vigorously
Label the vial with the date of reconstitution
Refrigerate immediately at 2-8°C

Reconstituted Solution Storage: Store reconstituted DSIP at 2-8°C for short-term use. For longer-term storage, aliquot into single-use portions and store at -20°C . Avoid repeated freeze-thaw cycles.

Protection from Light and Moisture:

Store in original packaging protected from light
Keep vials tightly sealed when not in use
Allow refrigerated vials to reach room temperature before opening to prevent condensation

Key Benefits

Premium Quality Manufacturing: GMP-certified production, ≥99% HPLC-verified purity with lot-specific COAs
Well-Characterized Nonapeptide: Over 45 years of published research since discovery in 1977
Delta Sleep Promotion: Specifically increases slow-wave sleep (NREM stage 3) without affecting REM sleep
Circadian Rhythm Research: Modulates suprachiasmatic nucleus (SCN) activity and clock gene expression
Stress Response Studies: Attenuates HPA axis activation and reduces stress-induced cortisol elevation
Neuroprotection Research: Protects neurons against excitotoxicity and oxidative stress
Blood-Brain Barrier Penetration: Naturally crosses the BBB to act on CNS sleep-regulating centers
Sleep Architecture Studies: Investigate sleep onset latency, total sleep time, and sleep stage distribution
Thermoregulation Research: Influences body temperature regulation linked to sleep-wake cycles
Melatonin Interaction: Modulates pineal melatonin secretion for circadian rhythm studies
Well-Characterized Safety Profile: Extensive preclinical safety data available
Comprehensive Documentation: Certificates of Analysis with batch-specific purity data
48-Hour EU & UK Delivery: Rapid shipping to research facilities across Europe
Batch Consistency: Rigorous quality control ensures lot-to-lot reproducibility
EU Sourced: Available from within the European Union

Frequently Asked Questions

Q: What is DSIP and how does it work?

A: DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated from the cerebral venous blood of sleeping rabbits . It specifically promotes delta sleep (slow-wave sleep, NREM stage 3) by binding to receptors in the hypothalamus and brainstem, modulating GABAergic, serotonergic, and orexinergic systems .

Q: What purity level can I expect when I buy DSIP from Eupharmaceutical?

A: All DSIP Peptide from Eupharmaceutical is tested to ≥99% purity by HPLC, with Certificates of Analysis provided with every order . Each batch is individually analyzed, ensuring you receive material suitable for rigorous research applications.

Q: What is the molecular weight and CAS number of DSIP?

A: DSIP has a molecular weight of 848.9 g/mol and CAS number 62568-57-4 . Its molecular formula is C₃₅H₄₈N₁₀O₁₅ and amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu .

Q: How should I store DSIP for long-term stability?

A: Store lyophilized DSIP powder at -20°C, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 24 months. For short-term use, store reconstituted solution at 2-8°C; for longer-term storage, aliquot and store at -20°C .

Q: What is the solubility of DSIP?

A: DSIP is highly soluble in sterile water, bacteriostatic water, and PBS . Reconstitute according to research protocol to achieve desired concentration.

Q: What research areas commonly use DSIP?

A: DSIP is widely used in sleep architecture and delta sleep research, circadian rhythm studies, stress response and HPA axis research, neuroprotection research, and neuroendocrine research .

Q: What is the half-life of DSIP?

A: DSIP has a plasma half-life of approximately 4-7 minutes in humans due to rapid proteolytic degradation . However, its effects on sleep architecture can persist beyond its plasma presence due to downstream signaling cascades.

Q: Do you ship DSIP to EU countries?

A: Yes. As a dedicated EU peptide supplier, we ship DSIP Peptide to all European Union member states with our guaranteed 48 hour delivery peptide service. Our EU fulfilment centre ensures rapid delivery without customs delays. All shipments use protective packaging to maintain compound integrity during transit.

Q: What documentation do you provide with DSIP orders?

A: Every order includes a Certificate of Analysis (COA) with batch-specific purity data . Additional documentation, including HPLC chromatograms and mass spectrometry data, is available upon request for researchers requiring comprehensive analytical verification.

Q: Do you offer bulk quantities of DSIP for institutional research?

A: Yes. We accommodate bulk orders for research institutions. Contact our team at contact@eupharmaceutical.com for volume pricing, custom requirements, and supply agreements for ongoing research programs. p s y c h e d e l i c g u i d e e x p l a i ned.

Advance Your Research with DSIP Peptide

Eupharmaceutical is your trusted source for DSIP Peptide, the premium choice for researchers investigating sleep architecture, circadian rhythms, and neuroendocrine regulation. With over 45 years of published research establishing its role as a specific delta sleep-promoting peptide, DSIP represents a foundational tool for understanding the molecular mechanisms of deep sleep and its regulation.

Whether you are exploring delta sleep mechanisms, designing circadian rhythm studies, investigating stress-sleep interactions, or researching neuroprotective pathways, our rigorously tested compound provides the quality and consistency your work demands.

Order today and experience the Eupharmaceutical difference – premium quality, rapid 48-hour delivery across the EU and UK, and expert support for the European research community.